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URL:https://lectures.london/imperial-college/human-immune-system-variation
 -development-and-the-microbial-roots-of-health/calender.ics
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DTSTART:20260527T163000
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SUMMARY:Human immune system variation\, development\, and the microbial ro
 ots of health
LOCATION:Imperial College: Lecture theatre 200\, City and Guilds Building
DESCRIPTION:Professor Petter Brodin\, Garfield Weston Chair of Neonatology
 \, and Professor of Paediatric Immunology\, explores how microbes in early
  life shape the developing immune system.\nPlease register to attend in pe
 rson. A live stream link for online attendance is available on this page.
  \nWe look forward to seeing you on Wednesday 27 May!\nImperial Inaugural
 s are term-time lectures that celebrate our newest Professors\, recognis
 ing their academic journey and showcasing their research.\nAbstract\n\nWhy
  does the same vaccine produce lifelong protection in some children and ba
 rely a trace in others? And why\, despite millions of years of evolution h
 oning our immune defences\, are allergies\, asthma\, and autoimmune disea
 ses rising steeply in modern societies? These questions animate the work o
 f my laboratory\, which applies systems immunology approaches to longitudi
 nal human cohorts to understand the forces that shape immune systems acros
 s the life course. \n\n\n\n\n\nWe have shown that the vast majority of im
 mune variation between individuals is driven not by genetics\, but by envi
 ronmental exposures ‚and that the most consequential of these occur in t
 he first weeks and months of life. The microbes that colonise the newbo
 rn intestine\, and the metabolites they produce\, act as critical calibrat
 ors of the developing immune system\, setting immunological trajectories f
 or health and disease that can persist for years. Using bifidobacteria as
  a paradigm\, we have demonstrated direct causal links between early mi
 crobial colonisation and immunological imprinting\, and identified sp
 ecific molecular mechanisms mediating these effects. \n\n\n\n\n\nAt Imper
 ial College London\, we now apply a unique miniaturized screening platform
  to test thousands of microbial metabolites for immunomodulatory activity\
 , with the aim of developing preventive interventions for children. By com
 bining state of the art technologies with rare and unique samples from y
 oung children\, in this lecture I will present a vision for precision pae
 diatric immunology\, one in which we learn from evolution to protect all 
 children from infections and immune-mediated disease from the very beginni
 ng of life. \nBiography\nThe Brodin lab develop and applies system immuno
 logy approaches to study human immune system variation in health and disea
 se and human immune system development early in life. The work of the grou
 p involves the elucidation of heritable and non-heritable factors that sha
 pe human immunity\, immune system development and adaptation to microbia
 l factors early in life as well as a research program in clinical applicat
 ion of systems immunology in children to diagnose and describe immune syst
 em dysregulation and enable precision medicine. To enable these activities
  the group develops novel experimental and computational methods to more c
 omprehensively and accurately monitoring immune systems in humans
URL;VALUE=URI:https://www.imperial.ac.uk/events/207311/human-immune-system
 -variation-development-and-the-microbial-roots-of-health/
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