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Stanford University

Crick Lectures are delivered by leading internationally-renowned scientists from the Francis Crick Institute and elsewhere and cover the full spectrum of biomedical research. They aim to be relatively accessible to scientists in all biomedical disciplines, whilst also offering something for the specialist.

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Michelle Monje, Milan Gambhir Professor of Pediatric Neuro-Oncology at Stanford University and a Howard Hughes Medical Institute Investigator gives this week's Crick lecture.

Biography

Michelle received her M.D. and Ph.D. in Neuroscience from Stanford and completed her residency training in neurology at the Massachusetts General Hospital/Brigham and Women's Hospital/Harvard Medical School Partners program, and then returned to Stanford for a clinical fellowship in pediatric neuro-oncology. Her research program focuses at the intersection of neuroscience, immunology and brain cancer biology with an emphasis on neuron-glial interactions in health and oncological disease. Her laboratory studies how neuronal activity regulates healthy glial precursor cell proliferation, new oligodendrocyte generation, and adaptive myelination; this plasticity of myelin contributes to healthy cognitive function, while disruption of myelin plasticity contributes to cognitive impairment in disease states like cancer therapy-related cognitive impairment. Her lab discovered that neuronal activity similarly promotes the progression of malignant gliomas, driving glioma growth through both paracrine factors and through electro-physiologically functional neuron-to-glioma synapses. Dr.Monje has led several of her discoveries from basic molecular work to clinical trials. 

Awards

Her work has been recognized with numerous honors, including an NIH Director’s Pioneer Award, a MacArthur Fellowship, the Richard Lounsbery Award from the National Academy of Sciences and election to the National Academy of Medicine.

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