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The Crick magazine, spring 2026

MRC Laboratory of Molecular Biology, Cambridge

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Lori Passmore is Head of the Mechanisms of Molecular Machines lab at the MRC Laboratory of Molecular Biology in Cambridge.

Using an integrated approach combining structural, biochemical and functional studies, Lori Passmore aims to reconstitute multi-protein complexes and their activities. She determines high-resolution structures of these complexes to understand their mechanisms.

Lori’s work focuses on understanding the mechanisms of protein complexes involved in regulating gene expression. This includes the cellular machinery that adds and removes poly(A) tails from mRNAs (CPF/CPSF, Ccr4-Not, Pan2-Pan3), and complexes involved in repair of DNA crosslinks (the Fanconi anaemia pathway). Lori’s lab has also developed new supports for electron cryo-microscopy (cryoEM) that reduce radiation-induced specimen motion to improve resolution.

Lori is originally from Canada and studied Biochemistry at the University of British Columbia in Vancouver.  In 1999, she moved to the UK for her PhD studies at The Institute of Cancer Research.  After completing her PhD, Lori moved to Cambridge where she was a Career Development Fellow at the MRC Laboratory of Molecular Biology, funded by a Beit Memorial Fellowship for Medical Research.  In 2009, Lori became a Group Leader at the MRC-LMB. In 2024 she was appointed Joint Head of Structural Studies Division. She is also a fellow and tutor at Clare Hall.

Lori is an EMBO Member and a Fellow of the Royal Society. She was awarded a Suffrage Science award in 2016 and the inaugural Elisa Izaurralde Award of the RNA Society in 2020.

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