Crick Lecture | Wei Yang

The Francis Crick Institute

May 21

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The Crick magazine, spring 2026

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK NIH)

Crick Lectures are delivered by leading internationally-renowned scientists from the Francis Crick Institute and elsewhere and cover the full spectrum of biomedical research. They aim to be relatively accessible to scientists in all biomedical disciplines, whilst also offering something for the specialist.

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Wei Yang is a Distinguished Investigator at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK NIH) which is one of the National Institutes for Health in the USA. She is Principal Investigator of the Mechanism of DNA Repair, Replication, and Recombination Section at the Laboratory of Molecular Biology at NIDDK.

Genomic DNA is susceptible to a variety of mutagenic processes. The YANG group studies mismatch repair, which corrects replication errors, translesion DNA synthesis, which completes DNA replication when normal polymerases are stalled by damaged bases, and V(D)J recombination, which uses sequence-specific nuclease RAG1/2 and Non-Homologous End Joining (NHEJ) to assemble millions of antigen receptor genes for lymphocyte maturation.

Majored in Biochem, 1980-83, Fudan University, Shanghai

B.A. in Biochem, 1985, SUNY at Stony Brook

Ph.D. in Biochem & Mol Biophys. with Wayne Hendrickson, 1991, Columbia University

Post-doc with Wayne Hendrickson, 1991-92, Columbia University

Post-doc with Tom Steitz, 1992-95, Yale University

Joined NIDDK, NIH in Dec. 1995, and got tenure in May 2000

The 2011 Dorothy Crowfoot Hodgkin award

American Association for the Advancement of Science (AAAS) fellow since 2012

National Academy of Sciences (NAS) member since 2013

American Academy of Arts and Sciences (AAAS) member since 2015

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