Steroids for BPD: Is intratracheal budesonide mixed with surfactant the silver bullet?” Prof Brett Manley

Imperial College

June 3

G16, Sir Alexander Fleming Building

Brett is a consultant neonatologist at The Royal Women’s Hospital in Melbourne and a Professor in the Department of Obstetrics, Gynaecology and Newborn Health at The University of Melbourne. He leads and collaborates on large clinical trials to improve outcomes for sick and preterm infants. Currently he is co-leading the implementation of the PLATIPUS Adaptive Platform Trial in Australia and New Zealand that will revolutionise the way clinical trials for preterm infants are conducted in the region.

Previous randomised trials have suggested that intratracheal budesonide, mixed with surfactant to deliver it effectively to the lungs, is a highly promising therapy to reduce the combined outcome of death or BPD in very low birth weight infants. The PLUSS trial aimed to confirm these findings in a large, pragmatic, international, randomised trial that enrolled over 1000 extremely preterm infants and completed recruitment in 2023. In his presentation, Brett will discuss the methods and results of the PLUSS trial and implications for clinical practice and research.

Side note: Brett has a dog called “Buddy”, which is short for “budesonide”.

Part of the Mohn / PaeCH joint seminar series for 2024.  Please join us in the lobby after the lecture for drinks and networking.

Further Information

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Getting the right early start to life is essential for a child’s development and their life-long health.

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