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The Francis Crick Institute
June 5
The Francis Crick Institute
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Altos Labs Cambridge Institute of Science
Crick Lectures are delivered by leading internationally-renowned scientists from the Francis Crick Institute and elsewhere and cover the full spectrum of biomedical research. They aim to be relatively accessible to scientists in all biomedical disciplines, whilst also offering something for the specialist.
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Dr Manuel Serrano Principal Investigator at the Altos Labs Cambridge Institute of Science gives this weeks lecture.
Manuel's team is currently focused on the mechanisms of cellular rejuvenation by partial reversible reprogramming and its similarities with tissue repair. The overarching goal of his research is to find pharmacological and dietary interventions that mimic partial reversible reprogramming and trigger rejuvenation.
Biography
Manuel Serrano obtained his PhD in 1991 in Madrid, Spain. In 1993, as a postdoctoral researcher in the laboratory of David Beach at Cold Spring Harbor Lab, NY, USA, he reported the discovery of the gene p16, a key anti-cancer gene and inducer of cellular senescence.
From 1997 to 2022, Serrano developed his career in Spain, initially in Madrid and from 2017 in Barcelona. His laboratory has made important contributions to the fields of cellular senescence and cellular reprogramming. Serrano pioneered the concepts of cellular senescence induced by oncogenic stress and cellular senescence during embryogenesis, both now well-established pillars in oncology and developmental biology, respectively. He also demonstrated that pluripotency reprogramming can be achieved within organisms and that senescent cells contribute key secreted factors for reprogramming to occur. In 2023, Serrano moved to Altos Labs in Cambridge, UK, where he continues investigating senescence and reprogramming with the aim of understanding and treating aging and its associated diseases.
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